View Product Catalogue

Search our database to view details of all our products.

More Details

View our Recipes

Click here to view our nutritional recipes

More Details

Latest news

CASE STUDY: Intensive Nutritional Intervention in a Frail, Elderly Patient

David Gray, Senior Specialist Dietitian at Guy’s and St Thomas’…

Case Study - Post-Pyloric feeding in gastroparesis: the role of high protein enteral feeds

Michelle Barry, Specialist Home Enteral Feeding Dietitian

There are several…

Available 1st March: 3 New Fortisip 2kcal Flavours

Help support your patients recovery with three tasty new flavours…

Nutricia Suggestion Engine - Conditions

Step 1

What information would you like to see?


Step 2

In order to show you information relevant to you, please select a condition of interest.

Step 3

Press the 'find' button below to find relevant articles,videos and podcasts.

You are viewing Consumer Information

Methylmalonic Acidaemia (MMA)

Methylmalonic acidaemia is a genetically inherited disease in which the body is unable to process certain amino acids and fats correctly. This leads to the accumulation of a molecule called methylmalonyl-CoA and other by-products in the blood, which poison the body and brain. Methylmalonyl-CoA is a form of methylmalonic acid. Methylmalonic acidaemia (-aemia = in the blood) is also known as methylmalonic aciduria (-uria = in the urine) since high levels of methylmalonyl-CoA are also excreted in the urine. The disease shows many similarities to propionic acidaemia.

There are several variants of methylmalonic acidaemia, which range in severity from mild to life threatening. Seizures and progressive brain damage are common. Stroke, due to abnormal blood flow to the brain, and coma are two other serious complications. Untreated, the prognosis is poor.

The main amino acids involved are isoleucine, valine, threonine and methionine. Amino acids are the building blocks of proteins. After eating proteins, the body ‘metabolises’ or breaks them down into amino acids. Animal proteins include dairy products, meat, eggs and fish. Proteins are also found in plants including soy, legumes, grains and nuts. The body uses the amino acids to make its own proteins essential for life – for example enzymes; structural proteins in muscles, hair, skin, cells and cartilage; proteins that generate movement in muscles; or those involved in cell functioning or immune responses. In periods of fasting or illness, the body often switches to use its own proteins, and stored fats, to generate energy. Isoleucine, valine, threonine and methionine are essential amino acids meaning that the body cannot make them. Therefore, these amino acids come from ingested protein or from the breakdown of previously ingested and stored proteins.

HCP Information for Methylmalonic Acidaemia (MMA)

The content provided by Nutricia is for information purposes only and is in no way intended to be a substitute for medical consultation with your doctor, dietitian or healthcare professional. The information, opinions, and recommendations presented in these pages are not intended to replace the care of your own doctor, dietitian or healthcare professional. Before you make any changes in the management of your diet / treatment or any other persons diet /treatment you should always consult your doctor, dietitian or healthcare professional. Although we carefully review our content, Nutricia cannot guarantee or take responsibility for the medical accuracy of documents we publish, nor can Nutricia assume any liability for the content of any web site linked to our site. © 2016 Nutricia. All rights reserved.