Oncology

Treatment of malnutrition in cancer

The goal of nutritional treatment with cancer is o improve function and outcome by:⁵

• Preventing and treating malnutrition
• Enhancing anti-tumour treatment effects
• Reducing adverse effects of anti-tumour therapies
• Improving quality of life

Much research exists to support the role of enteral nutrition in the treatment of malnutrition and weight loss in oncology patients.

• A systematic review showed that ONS significantly increased total energy intake in patients undergoing radiotherapy and improved protein intake.⁶
• The European Society for Parenteral and Enteral Nutrition (ESPEN) have concluded that ONS can be used in combination with dietary advice to prevent therapy-associated weight loss and interruption of therapy in non-surgical oncology patients.⁵
• In patients with pancreatic cancer an eicosapentanoeic acid (EPA) enriched ONS has been shown to increase energy and protein intake and to improve body mass.⁷
• Research suggests that, when taken appropriately, voluntary food intake is not substantially reduced among patients taking ONS.³
• A 50% reduction in complications and improved patient outcomes has been observed among cancer patients who used medical nutrition preoperatively.⁸
• Cancer patients who are initiated on ONS have, on average, a shorter hospital stay post-operatively than those who are not prescribed ONS, resulting in reduced healthcare costs.⁹

When should nutrition support be commenced in cancer patients?

ESPEN guidelines on nutrition in cancer state that enteral nutrition in the form of oral nutritional supplements or tube feeding should be started if malnutrition already exists or if food intake is markedly reduced for more than 7-10 days.⁵

As a guideline, malnutrition exists if a patient has:

• A Body Mass Index (BMI) less than 18.5
• Lost more than 10% of body weight in the past 3 to 6 months without trying
• A BMI less than 20 and has lost more than 5% of body weight over the past 3 to 6 months without trying.

What ONS are most appropriate for use in patients with cancer?

It is difficult to give exact guidance on which ONS is most suitable for cancer patients, as requirements will be determined by a range of factors including:

• Type of cancer (tumour site/stage/prognosis)
• Appetite/ability to tolerate large volumes (patients often experience early fullness and may only tolerate a "little and often" approach)
• Intake of normal food (are they eating quite well and only need an energy boost, or has their intake of normal foods declined significantly?)
• Taste preference (patients may experience taste changes associated with their treatment)
• Age of the patient

The differences between the nutrition requirements of a preterm infant and the nutrition provided in breastmilk highlight the requirement for additional supplementation in the form of either a human milk fortifier and/or a protein supplement.